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起止时间:2021-03-01到2021-06-27
更新状态:每5天更新一次
Chapter 1 Introduction Unit one Test
1、 Modern innovative drug discovery is a research process from genes to drugs. It has gone through three stages, which of the following is not?
A:Discovery of new targets
B:Discovery of lead compounds
C:Drug development
D:Consistency evaluation
答案: Consistency evaluation
2、 How many years does it take to discover modern innovative drugs?
A:2-3 years
B:5-8 years
C:12-15 years
D:20-30 years
答案: 12-15 years
3、 The concept of structural biology inspired by the structure of the target promoted the discovery of __, which is the First of Class drug of Puri series antihypertensive drugs and the prototype of drug design based on ____.
A:Enalapril, ligand pharmacophore
B:Captopril structure
C:Enalapril, structure
D:Captopril, ligand pharmacophore
答案: Captopril structure
4、 The main methods of drug design include ()
A:Drug design based on the interaction between the target and the drug
B:Computer aided drug design
C:Drug design based on early ADME/T evaluation
D:All of them
答案: All of them
5、 Modern drug design ideas based on the research of disease mechanisms, gene defects and other signal pathways discovered by _____ as the core reflect the new progress and new trends in the contemporary drug discovery field.
A:Random screening
B:Combinatorial chemistry
C:High-throughput screening
D:Target
答案: Target
6、 ___ is the main way of classic drug discovery.
A:High-throughput screening
B:Random screening
C:Target-based screening
D:Pharmacophore model screening
答案: Random screening
7、 The target is ______ with a specific function in the body, and the drug exerts its efficacy by combining with it.
A:organ
B:organization
C:biomacromolecule
D:cell
答案: biomacromolecule
8、 Which of the following is not a requirement for an effective drug?
A:Interact with target
B:Binding to plasma proteins
C:Maintain an appropriate concentration at the target
D:Have enough time to interact with the target
答案: Binding to plasma proteins
9、 Which of the following does not fall into the category of drug-receptor interaction theory?
A:Lipinski rule
B:Lock and key theory
C:Molecular recognition
D:Induced fit theory
答案: Lipinski rule
10、 What are the two classifications of structure-based drug design?
A:Direct drug design, indirect drug design
B:Fragment drug design, drug property design
C:Direct drug design, fragment drug design
D:Direct drug design, drug property design
答案: Direct drug design, indirect drug design
11、 Indirect drug design is based on the design of the three-dimensional structure of ____.
A:Receptor
B:Protein
C:Compound
D:Ligand
答案: Ligand
12、 What are the ways to discover lead compounds?
A:Screening approach
B:Structure-based drug design
C:Property-based drug design
D:All of them
答案: All of them
Chapter 2 Drug Targets and Theories Unit two Test
1、 Which of the following scientists proposed the idea of side chain that is the prototype of modern drug target theory?
A:Gerhard Domagk who invented Prontosil
B:Paul Janssen who invented haloperidol and fentanyl
C:Paul Ehrlich who invented Ars vannamei
D:James Black who invented propranolol and cimetidine
答案: Paul Ehrlich who invented Ars vannamei
2、 Which of the following technologies is not a target structural biology research technology?
A:Cryo-EM technology
B:NMR technology
C:X-ray single crystal diffraction technique
D:Computer tomography
答案: Computer tomography
3、 The following are not drug targets
A:Dopamine receptor
B:Serotonin reuptake transporter
C:Amoeba
D:Tetrahydropteroate synthase
答案: Amoeba
4、 The following are not suitable as drug targets
A:Histamine receptor
B:Dihydrofolate reductase
C:Tumor necrosis factor
D:All of the above can be used as drug targets
答案: All of the above can be used as drug targets
5、 The following statement about the target is incorrect.
A:Target theory is the foundation of modern drug discovery
B:Target theory is based on the discovery of drugs through phenotypes
C:Cytokines can also be targets of drug action
D:The druggability of the target is the key to the verification of the target
答案: Target theory is based on the discovery of drugs through phenotypes
6、 The research hypothesis of the second-generation anti-tumor drug imatinib is
A:Philadelphia chromosome aberration and BCR-ABL fusion gene expression
B:Tumor angiogenesis
C:EGFR level overexpression
D:Inactivation of p53 tumor suppressor gene
答案: Philadelphia chromosome aberration and BCR-ABL fusion gene expression
7、 Muscarinic acetylcholine receptors belong to
A:Ligand-gated ion channel receptor
B:G protein coupled receptor
C:Nuclear receptor
D:Receptor tyrosine kinase
答案: G protein coupled receptor
8、 The substrate of monoamine oxidase B is
A:Serotonin
B:Norepinephrine
C:Dopamine
D:Glutamate
答案: Dopamine
9、 Clenbuterol, a wheezing drug that belongs to β2 adrenergic receptor, also known as clenbuterol
A:Agonist
B:Antagonist
C:Inverse agonist
D:Allosteric modulator
答案: Agonist
10、 Regarding the druggability statement, which statement is correct:
A:GPCR-like membrane protein receptors belong to the target type with lower Druggability
B:Refers to whether the target is druggable
C:Low druggability of listed drugs targets
D:High druggability without listed drugs targets
答案: Refers to whether the target is druggable
11、 For the requirements of drug targets, what is incorrect is:
A:The signal pathway where the drug target is located must have a critical impact on the disease
B:The drug target must have a key role in the function of the signal pathway
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