对应课程:点击查看
起止时间:2020-12-09到2021-02-28
更新状态:已完结
Chapter one： The background of CADD Unit test 1
1、 Which of the following diseases could be treated by the “Glenin” in the movie “Dying to survive” ?
A:Heart disease
B:Leukemia
C:Cerebrovascular disease
D:Cirrhosis
答案: Leukemia
2、 In addition to being able to speed up target discovery, what is the other advantage of CADD ?
A:Increase drug targets
B:Improve the inclusion of targets
C:Find more targets
D:Improve the accuracy of target discovery
答案: Improve the accuracy of target discovery
3、 What are the main problems of CADD at present ?
A:Authenticity and usability of three-dimensional protein structure
B:The way of receptor ligand interaction
C:Whether the designed molecule can be chemically synthesized
D:Drug transport, metabolism and side effects in vivo
答案: Authenticity and usability of three-dimensional protein structure;
The way of receptor ligand interaction;
Whether the designed molecule can be chemically synthesized;
Drug transport, metabolism and side effects in vivo
4、 Computer aided drug design uses pharmacophore models, quantum mechanics, molecular dynamics, the quantitative structure-activity relationship (QSAR), etc, on enzyme or receptor, so as to achieve the purpose of drug design.
A:正确
B:错误
答案: 正确
5、 At present, a new drug can be designed automatically by computer.
A:正确
B:错误
答案: 错误
6、 A lead compound in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters.
A:正确
B:错误
答案: 正确
Chapter two： The past life of CADD Unit test 2
1、 What are the targets of drug action ?
A:Recipient
B:ion channel
C:enzyme
D:Endogenous small molecular matter
答案: Recipient;
ion channel;
enzyme;
Endogenous small molecular matter
2、 Which of the following are endogenous ligands of receptors?
A:Neurotransmitter
B:hormone
C:Autoactive substance
D:Mycoplasma
答案: Neurotransmitter;
hormone;
Autoactive substance
3、 What are the characteristics of receptors ?
A:Specificity
B:High affinity
C:Saturability
D:Reversibility
答案: Specificity;
High affinity;
Saturability;
Reversibility
4、 The specificity of drug action depends on the specificity of drug molecule binding to its receptor.
A:正确
B:错误
答案: 正确
5、 Modern drug discovery also has its limitations. Its research object is “drug-disease” relationship rather than “target-drug” relationship.
A:正确
B:错误
答案: 错误
6、 The substances that can specifically bind to the receptors in the body are called ligands.
A:正确
B:错误
答案: 正确
7、 The receptor is the biomacromolecule that can interact with drugs and initiate cell reaction.
A:正确
B:错误
答案: 正确
Chapter three： The present life of CADD Unit test 3
1、 What is the most common method used to build QSAR model ?
A:Simplex algorithm
B:Partial least square method
C:least square method
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